Leukemia is a gathering of malignancy began from bone marrow and will deliver impact on white platelet which will thus lead to anomaly. Presently the development of impact will continue by the undeveloped and juvenile WBC. Leukemia is an expansive term covering a range of infections. The focal point of enthusiasm for oncology especially in leukemia vitamin C has the best technique by which it demonstrates the more noteworthy outcome. An undeveloped cell takes amazingly elevated amounts of Ascorbic acid, which at that point allot their capacity and subdue the improvement of leukemia. Vitamin C levels manage HSC numbers and capacity. At the point when ascorbate levels are reduced, it can give the power to the deactivation of a catalyst called Tet2. The inactivation of TET2 is represented by change and insufficiency of vitamin-C may constrain Tet2 work in tissues in a way that builds the danger of leukemia. TET2 function is actually strengthen by ascorbate level. By encouraging DNA demethylation, tremendous-dose of ascorbate treatment can persuade stem cells to develop and the growth of cancerous stem cells will retarded by the tremendous dose of ascorbate level as investigated in mice. Tremendous dose of ascorbate might become a safe treatment for blood diseases caused by TET2-deficient leukemia stem cells, most likely in combination with other targeted therapies.
Leukemia, Blast cells, Vitamin-C, Tet2, DNA Methylation
International Journal of Trend in Scientific Research and Development - IJTSRD having
online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International
Journal which provides rapid publication of your research articles and aims to promote
the theory and practice along with knowledge sharing between researchers, developers,
engineers, students, and practitioners working in and around the world in many areas
like Sciences, Technology, Innovation, Engineering, Agriculture, Management and
many more and it is recommended by all Universities, review articles and short communications
in all subjects. IJTSRD running an International Journal who are proving quality
publication of peer reviewed and refereed international journals from diverse fields
that emphasizes new research, development and their applications. IJTSRD provides
an online access to exchange your research work, technical notes & surveying results
among professionals throughout the world in e-journals. IJTSRD is a fastest growing
and dynamic professional organization. The aim of this organization is to provide
access not only to world class research resources, but through its professionals
aim to bring in a significant transformation in the real of open access journals
and online publishing.