Lack of association between CD45 C77G polymorphism and  multiple sclerosis in Kashmir

Amrina Shafi; Mudasir A Mir; Insha Zahoor

Title:
Lack of association between CD45 C77G polymorphism and multiple sclerosis in Kashmir

Authors:
Insha Zahoor | Amrina Shafi | Mudasir A Mir
DOI:
https://doi.org/10.31142/ijtsrd5813

Cite This Article :

Insha Zahoor | Amrina Shafi | Mudasir A Mir "Lack of association between CD45 C77G polymorphism and multiple sclerosis in Kashmir" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6, October 2017, pp.1333-1337, URL: https://www.ijtsrd.com/papers/ijtsrd5813.pdf

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Abstract :
Multiple sclerosis (MS) is a severe disabling and demyelinating disease of the nervous system. Its etiology involves profound genetic component. The latest contender known to have been correlated with MS is protein tyrosine phosphatase receptor-type C (PTPRC or CD45); however, to date its role remains contentious. The aim of the current study was to examine the association of functionally significant exon 4 C77G polymorphism of CD45 with MS in Kashmiri population from Indian subcontinent. The preliminary findings of our study revealed absence of C77G in majority of the cases as well as controls. These findings strongly suggest that the alterations in CD45 are sporadically associated with the genesis of MS. In conclusion, results from our study are in accordance with some of the international studies; however, more studies with large datasets from Kashmir as well as other ethnic populations are warranted to validate the above preliminary findings and demonstrate the role of CD45 C77G polymorphism in MS pathogenesis.

Keywords :
MS; genetics; CD45; C77G; polymorphism; Kashmir

Publication Details:

Unique Identification Number : IJTSRD5813

Published In : Volume-1 | Issue-6, October 2017

Page Number(s) : 1333-1337

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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