Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate – Bromide Mixture

G. T. Naidu; G. Abdul Huq; I. Lakshmi Prasanna

Title:
Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate – Bromide Mixture

Authors:
I. Lakshmi Prasanna | G. T. Naidu | G. Abdul Huq
DOI:
https://doi.org/10.31142/ijtsrd18253

Cite This Article :

I. Lakshmi Prasanna | G. T. Naidu | G. Abdul Huq "Spectrophotometric Oxidation Method for the Determination of Teneligliptin by Using Bromate – Bromide Mixture" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-5, August 2018, pp.2094-2098, URL: https://www.ijtsrd.com/papers/ijtsrd18253.pdf

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Abstract :
A sensitive, precise, accurate, simple and rapid spectrophotometric method has been developed for the estimation of Teneligliptin in pharmaceutical formulations and in the drug dosage form. During the course of study, it is observed that acidic solution of the drug formed the oxidation product with Bromate – Bromide mixture. This property of the drug is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed ?max at 250 nm. The linearity range for Teneligliptin is found to be 10 µg/ml to 250 µg/ml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 1.1645×104 lit/ mole/cm and 0.0366 µg/ ml/cm2 respectively.

Keywords :
Spectrophotometry, Teneligliptin, Bromate-Bromide oxidant, Pharmaceutical formulations

Publication Details:

Unique Identification Number : IJTSRD18253

Published In : Volume-2 | Issue-5, August 2018

Page Number(s) : 2094-2098

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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