Oxidative stress has continued to play major roles in the etiology of many metabolic diseases, diabetes and obesity inclusive. The study on oxidative stress in diabetic-obese patients was carried out with patients from two tertiary hospitals in Abia State Nigeria who gave their consent to participate in the study. A total of 120 patients (18 years and above) who were stratified into five different age groups were enrolled for the study. Following approved protocols fasting blood samples were collected and a semi-structured questionnaire used to collect other data needed for the study. Data was analyzed using T-test and SPSS version 20.0 software and result considered significant at p < 0.05. The results showed that body mass index (BMI) were higher in females than males (37.20 vs 35.12) kg/m2. The oxidative stress markers or parameters of the experimental groups follow a uniform trend of significant increases in Malondialdehyde (MDA), and significant decreases in enzymes: Glutathione peroxidases (GPx) and Superoxide dismutase (SOD) and vitamins (C and E). Also middle-aged patients (30 - 50 years) were equally affected with diabetes and more in females than males. Generally increased oxidative stress or impaired antioxidant defense system in diabetic-obese condition may contribute to increased metabolic damage.
Anti-Oxidant defense system, Superoxide dismutase, obesity, Malondialdehyde
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