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Computational prediction of damage associated non synonymous SNPs of CYP17A1 and CYP19A1 gene

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Computational prediction of damage associated non synonymous SNPs of CYP17A1 and CYP19A1 gene


Richa Bhatnager | Ranjeet Kaur | Amita Suneja Dang | Twinkle Dahiya

https://doi.org/10.31142/ijtsrd3581



Richa Bhatnager | Ranjeet Kaur | Amita Suneja Dang | Twinkle Dahiya "Computational prediction of damage associated non synonymous SNPs of CYP17A1 and CYP19A1 gene" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6, October 2017, pp.635-646, URL: https://www.ijtsrd.com/papers/ijtsrd3581.pdf

The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP17A1 and CYP19A1 are the key proteins involved in steroidogenesis. Majority of polymorphisms have yet not been evaluated for their possible damaging effects on protein structure and function of both the genes. In present analysis, we tried to find out the effect of damage associated nsSNPs of both CYP17A1 and CYP19A1 gene by using various computational algorithms. Out of 205 and 246 nsSNPs reported for CYP17A1 and CYP19A1 gene, total 13 and 7 were predicted to affect the structure and function respectively. R125Q, R416H and F453S substitutions of CYP17A1 gene were not reported previously hence provide the new dataset of unexplored SNPs for their validation. By our results we also found that substitution of mainly Arginine or Phenyl alanine within conserved domain of redox binding, heam binging and redox partner site would cause partial or complete loss of function of both CYP17 and CYP19 gene.

CYP450, Steroidogenesis, Aromatase, SNP, Oestrogen, Testosterone


IJTSRD3581
Volume-1 | Issue-6, October 2017
635-646
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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