The novel coronavirus SAR-CoV-2 has resulted in huge wave of worldwide fear by its contagious nature, virulence and high mortality. Persistence condition of the disease with T-cells and Natural killer cells exhaustion leads to Lymphopenia or Lymphocytopenia. Lymphocytopenia is a condition of low lymphocyte count in the blood. Lymphocytopenia is an important adverse effect of COVID-19 as well as negative prognostic marker in many malignancies. It leads to hyper activation of immune system that can cause immunosuppression and promote cytokine storm that eventually leads to multi-organ failure and death. Restoration of lymphocytes and its function would be helpful to boost the immune response against COVID-19 disease. This review analyses the possible causes that may lead to the lymphocyte reduction in COVID-19 patients, and highlighting the possible therapeutic strategies that will help to control and prevent lymphocytopenia in COVID-19 patients.
COVID-19, SAR-CoV-2, T-lymphocytes, NK cells, Lymphocytopenia, cytokine storm
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