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Production of Oral IgY Antibody- A Novel Immunotherapy against Clostridium Difficile

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Production of Oral IgY Antibody- A Novel Immunotherapy against Clostridium Difficile


Dr. R. Mahenthiran | Sornambiga Ravi | Sri Alamelu. K. V



Dr. R. Mahenthiran | Sornambiga Ravi | Sri Alamelu. K. V "Production of Oral IgY Antibody- A Novel Immunotherapy against Clostridium Difficile" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3, April 2021, pp.536-546, URL: https://www.ijtsrd.com/papers/ijtsrd39892.pdf

Clostridium difficile is the leading cause of nosocomial infectious Antibiotic – Associated Diarrhea (AAD). Like most other enteric bacterial pathogens, Clostridium difficile causes disease with a wide spectrum of severity ranging from mild ‘nuisance’ diarrhea with a normal colonic mucosa to pseudo membranous colitis, which is characterized by severe abdominal pain, diarrhoea and fever. Constitutional signs such as fever, fatigue and loss of appetite are prominent. The incidence of infection with this organism is increased in hospitals worldwide, due to the use of broad-spectrum antibiotics. Clostridium difficile is transmitted from person to person by the fecal-oral route. However, the organism forms large numbers of heat-resistant spores which remain viable in the hospital or nursing home environment for long periods of time. Infection rates for Clostridium difficile are reported to be around 10% after 2 weeks of hospitalization but may reach 50% after 4 or more weeks. Each year in North America, 1–3% of hospitalized patients receiving antibiotics become infected with C. difficile, leading to thousands of deaths and over $1 billion in associated costs to the health-care system.

Clostridium difficile, IgY, SDS-PAGE, ELISA


IJTSRD39892
Volume-5 | Issue-3, April 2021
536-546
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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