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Identification and Antifungal Susceptibility Pattern of Candida Species Causing Oral Thrush and Vaginal Candidiasis

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Identification and Antifungal Susceptibility Pattern of Candida Species Causing Oral Thrush and Vaginal Candidiasis


Adindu J. C. | Anyamene C. | Chukwukaelo D. C.



Adindu J. C. | Anyamene C. | Chukwukaelo D. C. "Identification and Antifungal Susceptibility Pattern of Candida Species Causing Oral Thrush and Vaginal Candidiasis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-2, April 2023, pp.120-126, URL: https://www.ijtsrd.com/papers/ijtsrd53899.pdf

Candidiasis: A disease, which though common yet often neglected, has caused more havoc than reported and with the increase in antimicrobial resistance, antifungal agents that are more effective are to be used. The aim of this work is to identify Candida species causing oral thrush and vaginal candidiasis in Awka, Nigeria and evaluate the effect of Fluconazole and Nystatin in-vitro against them. Using standard microbiological tests in identification, 80 samples (43.24%) were positive for Candida out of the 185 samples gotten from the study subjects. Candida albicans (55%), C.tropicalis (35%) and C.glabrata (10%) were isolated from the oral cavity while Candida albicans (35%), C.krusei (31.67%), C.tropicalis (15%), C.dublinensis (8.33%), C.glabrata (5.00%), and C.parapsilosis (5.00%) were isolated from the vagina. Fluconazole (50µl) and Nystatin (100 Units) were employed in the anticandidal sensitivity test using agar well diffusion method. More susceptibility to Nystatin than Fluconazole was recorded. From the oral cavity, C.tropicalis was the most susceptible while C.glabrata and C.parapsilosis were the most susceptible species from the HVS samples. This reveals the increase in isolation of non-albicans Candida (NAC) and their growing resistance to Fluconazole which is commonly used hence the need to employ Nystatin as a first line drug for the treatment of oral thrush and vaginal candidiasis.

Oral thrush; Vaginal candidiasis; Fluconazole; Nystatin; Candida species


IJTSRD53899
Volume-7 | Issue-2, April 2023
120-126
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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