Premature ovarian failure syndrome is a symptom complex characterized by hypergonodotropic amenorrhea in women under 40. Known causes include: 1. Genetic aberrations that can affect the X chromosome or autosomes. 2. Autoimmune damage to the ovaries, as evidenced by the observed association of POF with other autoimmune disorders. 3. Iatrogenic after surgery, radiotherapy or chemotherapy, as in malignant neoplasms. 4. Environmental factors such as viral infections and toxins, the mechanism of action of which is not known.
Premature ovarian failure syndrome, follicle-stimulating hormone, family history
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