Colorimetric Determination of Stability Constant of Trimethoprim-Cu(II) Complex at Different Temperatures by Continuous Variation Method

I. E. Otuokere; K. K. Igwe; O. V. Ikpeazu

Title:
Colorimetric Determination of Stability Constant of Trimethoprim-Cu(II) Complex at Different Temperatures by Continuous Variation Method

Authors:
O. V. Ikpeazu | I. E. Otuokere | K. K. Igwe

Cite This Article :

O. V. Ikpeazu | I. E. Otuokere | K. K. Igwe "Colorimetric Determination of Stability Constant of Trimethoprim-Cu(II) Complex at Different Temperatures by Continuous Variation Method" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5, August 2020, pp.252-256, URL: https://www.ijtsrd.com/papers/ijtsrd31849.pdf

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Abstract :
Trimethoprim is an antibiotic that is mainly used for the treatment of bladder infections. Continuous variation method was applied in the calculation of stability constant of trimethoprim-Cu(II) complex depending on the theoretical explanation of the stoichiometry. The formation of Cu(II) complex with trimethoprim was studied colorimetrically at an absorption maximum of 480 nm at 25, 30, 35 and 40 oC. The data showed that Cu(II) and trimethoprim combine in the molar ratio of 1:1 at pH 7.4 with ionic strength maintained using 0.1M KNO3. Calculated stability constants values were 6.00 x 104, 3.80 x 104, 2.61 x 104 and 1.89 x 104 at 25, 30, 35 and 40 oC respectively. Calculated ?GO for the complex were -2.73 x 104, -2.66 x 104, -2.60 x 104 and -2.56 x 104 at 25, 30, 35 and 40 oC respectively. The stoichiometry, stability constant and Gibbs free energy results suggested that trimethoprim used in the study is a potent chelating agent and can be an efficient antidote in the therapy of Cu(II) overload or poisoning.

Keywords :
Trimethoprim, copper, complex, stability constant

Publication Details:

Unique Identification Number : IJTSRD31849

Published In : Volume-4 | Issue-5, August 2020

Page Number(s) : 252-256

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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