Teneligliptin is drug used against type 2 diabetes mellitus and it is also a member of class of anti-diabetic drugs known as dipeptidyl peptidase-4 inhibitors or "gliptins". A simple, sensitive and accurate RP-HPLC method has been developed for the determination of Teneligliptin in bulk formulation. The ?max of the Teneligliptin was found to be 246 nm in Methanol: Phosphate buffer pH:3 [70:30 (v/v)]. The method shows high sensitivity with linearity 10 to 50 µg/ml (regression equation: y = 54647x - 74133; r2 = 0.9968). The various parameters according to ICH guidelines are followed for validating and testing of this method. The Detection limit and quantitation limit were found to be 0.109 µg ml –1 and 0.3305 µg ml–1 in Methanol: Phosphate buffer pH: 3 [70:30 (v/v)] respectively. The % purity of tablet formulation was found to be 99.57%. The results demonstrated that the procedure is accurate, specific and reproducible (RSD < 2%), and also being simple, cheap and less time consuming and appropriate for the determination of Teneligliptin in bulk and pharmaceutical formulation.
Teneligliptin, dipeptidyl peptidase-4 inhibitors
International Journal of Trend in Scientific Research and Development - IJTSRD having
online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International
Journal which provides rapid publication of your research articles and aims to promote
the theory and practice along with knowledge sharing between researchers, developers,
engineers, students, and practitioners working in and around the world in many areas
like Sciences, Technology, Innovation, Engineering, Agriculture, Management and
many more and it is recommended by all Universities, review articles and short communications
in all subjects. IJTSRD running an International Journal who are proving quality
publication of peer reviewed and refereed international journals from diverse fields
that emphasizes new research, development and their applications. IJTSRD provides
an online access to exchange your research work, technical notes & surveying results
among professionals throughout the world in e-journals. IJTSRD is a fastest growing
and dynamic professional organization. The aim of this organization is to provide
access not only to world class research resources, but through its professionals
aim to bring in a significant transformation in the real of open access journals
and online publishing.