The reaction of phenyl hydrazine with ethyl acetoacetate gave 3-methyl-1-phenyl-5-pyrazolone(1), which then treated with malonitrile and benzaldehyde to give 6-amino-3-methyl-1,4-dihydropyrano [2,3-b]pyrazole-5-carbonitrile(2) which considered assynthone for prepare some new pyrazole derivatives (3a-j).The structure of the prepared compounds was suggested in the IR , 1 H-NMR, 13 C-NMR and UV Spectroscopy. Many steps starting from esterification of isophthalic acid to yield diester compound [I] which was converted to their acid hydrazide [II], then the later compound reacted with ethylacetoacetate to yield pyrazol-5-one compound [III]. Afterword added acetyl chloride to give the compound [IV], there action of this compound with theiosemicarbazide ledto produce a new carbothioamide compound [V], Which was reacted with ethyl chloro acetate to yield thethioxoimidazolidin compound [VI]. The condensation reaction of this compound with different substituted aldehyde give new alkene derivatives[VII]a-d. The synthesized compounds were characterized by melting points , FT-IR ,1H-NMR and Mass spectroscopy.
pyrazole, synthesis, characterization, heterocyclic, compounds, spectroscopy, melting points
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