BACKGROUND: Iron deficiency anemia (IDA) is particularly high in children in developing countries .Sympathetic skin response (SSR) is a polysynaptic reflex, and its final efferent pathway involves pre- and post-ganglionic sympathetic sudomotor fibers that ultimately activate the sweat glands through sympathetic outflow . The aim of this study was to investigate whether IDA is involved in SSR. METHODS: 24 patients (17 girls, 7 boys) with IDA and 20 healthy children (11 girls, 9 boys) were enrolled in the study. RESULTS: Significant differences were observed between the palmar SSR results (latency, ms) of the patient and the control groups (1.09±0.24, 0.92±0.30, p= 0.048). There was no correlation between ferritin levels and SSR results of the patient group ( p=0.65 ). CONCLUSIONS: The evidence from this preliminary study suggests that efferent C fibers of the sympathetic nervous system may not intact in IDA. The sudomotor autonomic function test may be useful to detect autonomic involvement earlier.
Iron deficiency anemia, sympathetic skin response, children
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