Gene Expression and Pathway Detection for Diabetic Nephropathy using Computational Intelligence in Bioinformatics

Tanvi Shinde; Aarti Pundalik | Poonam Kedari; Dr. Brijendra Gupta

Title:
Gene Expression and Pathway Detection for Diabetic Nephropathy using Computational Intelligence in Bioinformatics

Authors:
Dr. Brijendra Gupta | Tanvi Shinde | Aarti Pundalik | Poonam Kedari

Cite This Article :

Dr. Brijendra Gupta | Tanvi Shinde | Aarti Pundalik | Poonam Kedari "Gene Expression and Pathway Detection for Diabetic Nephropathy using Computational Intelligence in Bioinformatics" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5, August 2022, pp.48-54, URL: https://www.ijtsrd.com/papers/ijtsrd50423.pdf

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Abstract :
It has been observed that in high blood sugar levels over time these high glucose level can damage various area of the body including cardiovascular system and kidneys. The kidney damage that results is known as “Diabetic nephropathy “.Diabetes plays a critical role in public health concern with rates of diabetes increasing globally and approximately 40% of affected individuals developing diabetic nephropathy. We have taken bioinformatics and computational approach to studying identification of diabetic nephropathy associated genes by literature mining for gene expression and how the genes affected the pathways (DN).Numerous datasets has been evaluated for Diabetic nephropathy occurs only in a minority of subjects with either type 1 or type 2 diabetes and seems to result from the interaction between genetic susceptibility and environmental insults and risk factors for the development of diabetic nephropathy includes ethnicity and inherited genetic differences and Hyperglycemia and arterial hypertension and other risk factors are smoking dyslipidemia proteinuria, glomerular hyperfiltration and factors.Our result have been evaluated how the pathways are been affected in diabetic nephropathy, the pathogenesis of diabetic nephropathy and gene mapping also the development of diagnostic.

Keywords :
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Publication Details:

Unique Identification Number : IJTSRD50423

Published In : Volume-6 | Issue-5, August 2022

Page Number(s) : 48-54

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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