Clinical trials are pivotal in advancing precision medicine, aiming to tailor treatments based on individual patient characteristics. Traditional clinical trial designs often face challenges in adapting to the complexities of personalized therapies, leading to inefficiencies and delays in drug development. Adoptive design strategies, such as adaptive trials and basket trials, offer promising alternatives by enabling real-time adjustments based on accumulating data. These approaches optimize trial efficiency, enhance patient stratification, and facilitate rapid identification of effective treatments for targeted patient populations. This review explores the principles, benefits, challenges, and recent advancements in adoptive design strategies within the context of precision medicine, highlighting their potential to accelerate the translation of genomic insights into clinical practice.
precision medicine, adaptive design, clinical trials, personalized medicine, adoptive design, basket trials, adaptive trials, genomic medicine, patient stratification, drug development
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