Background: Down Syndrome has been one of the emerging threats in current society with high prevalence rate of around 3000-5000 annual birth. This requires a screening and analysis of the aetiologies and other pathophysiological factors leading to the increase in current scenario. Objective: ? To find out the root cause of Down Syndrome ? To ruled out the exact cause how oxidative stress impact in Down syndrome ? To ruled out the exact cause how delayed pregnancy or advanced age of pregnancy impact in Down Syndrome Materials & Methods: This research has been based on the approach of mixed research methodology following interpretivism and positivism research philosophy where set of different families have been selected to isolate the changes evident within them for the pathogenesis of Down syndrome Results: It has been found that the evidence of trisomy is the evident feature and not the actual cause where generation of oxidative stress among the families as well as multi-factorial pathways regulate the pathophysiology Conclusion: Hence, considering the basic family pathology and maintaining appropriate psychophysiological correlation among the family-society could reduce the increasing threat in generation of Down Syndrome among foetus.
Down Syndrome, Trisomoy, HCR, Threat, Pathogenesis
International Journal of Trend in Scientific Research and Development - IJTSRD having
online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International
Journal which provides rapid publication of your research articles and aims to promote
the theory and practice along with knowledge sharing between researchers, developers,
engineers, students, and practitioners working in and around the world in many areas
like Sciences, Technology, Innovation, Engineering, Agriculture, Management and
many more and it is recommended by all Universities, review articles and short communications
in all subjects. IJTSRD running an International Journal who are proving quality
publication of peer reviewed and refereed international journals from diverse fields
that emphasizes new research, development and their applications. IJTSRD provides
an online access to exchange your research work, technical notes & surveying results
among professionals throughout the world in e-journals. IJTSRD is a fastest growing
and dynamic professional organization. The aim of this organization is to provide
access not only to world class research resources, but through its professionals
aim to bring in a significant transformation in the real of open access journals
and online publishing.