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Hepato-Protective Assessment of Pawpaw Leaves, Neem, Lemon Grass and Acts on Plasmodium Berghei Parasitized Wistar Rats

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Hepato-Protective Assessment of Pawpaw Leaves, Neem, Lemon Grass and Acts on Plasmodium Berghei Parasitized Wistar Rats


Nnyaha Anthonia E. | Igbokwe Ugochukwu V. | Okonkwo Onyeka Chukwudi | Ajeka Prisca O. | Nwaissac Ikechukwu S. | Okpa Precious N.



Nnyaha Anthonia E. | Igbokwe Ugochukwu V. | Okonkwo Onyeka Chukwudi | Ajeka Prisca O. | Nwaissac Ikechukwu S. | Okpa Precious N. "Hepato-Protective Assessment of Pawpaw Leaves, Neem, Lemon Grass and Acts on Plasmodium Berghei Parasitized Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5, August 2021, pp.2024-2030, URL: https://www.ijtsrd.com/papers/ijtsrd46292.pdf

Malaria is a major concern in Nigeria, and stands as the second leading cause of death from all infectious disease in Africa. Several studies have reported the damaging effect of the parasite to various body organs especially the liver. Reports over time has shown the benefits of various plants extracts in ethno-medicine. However, not much have been done on the effects of some of these extracts in combined form on its hepato-protective assessment in comparison with any known ACT based anti-malaria. The focus of this study was to explore the hepato-protective properties of ethanoic extract of Carica papaya Linn, AzadirachtaIndica, CymbopogonCitratusagainst ACT based antimalarial therapy on plasmodium berghei parasitized wistar rats. Phytochemical analysis of the extracts were done according to the method described by Treaseand Evans. Hepato-protective assessment were done using the liver function tests and assay of the liver histology respectively. One hundred and ten (110) rats distributed into 11 groups, each group having 10rats were used for the experiment. Negative control received just feed and water, Positive control were induced with the malaria parasite and given feed and water only. The tests groups were induced with malaria, received feed and water and treated with 500mg/kg, 250mg/kg and 165mg/kg doses of the extracts, both individually and in combined forms, as well as the standard ACT anti-malaria. Phytochemical screening showed that the plant extracts possessed high concentration of Tannins, Flavonoids, Saponins and Alkaloids. Plasmodium berghei increased the activities of ALP, ASP and ALT when compared with the positive control group. This may be attributed to increase in functional capacity of the liver as a result of the presence of the infection for the tests groups. Treatment with the plant extracts decreased ALP and ALT levels significantly (P<0.05), as well as AST levels except for the Neem extract. Histological examination of the liver of test animals showed no extensive damage to the tissue by the individual extracts when compared to the negative control group.

Hepato-protective, AzadirachtaIndica, Carica papaya Linn, CymbopogonCitratus, ethanol extract, plasmodium berghei, ACTs


IJTSRD46292
Volume-5 | Issue-5, August 2021
2024-2030
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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