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Combination Therapy of Carica Papaya and Vernonia Amygdalina Leaf Extracts are as Efficacious as Acts

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Combination Therapy of Carica Papaya and Vernonia Amygdalina Leaf Extracts are as Efficacious as Acts


Ajeka Prisca Ojochogu | Igbokwe Ugochukwu Vincent | Okonkwo Onyeka Chukwudi | Nnyaha Anthonia. E. | Ikechukwu Samuel Nwaisaac | Okpa Precious Nwaka



Ajeka Prisca Ojochogu | Igbokwe Ugochukwu Vincent | Okonkwo Onyeka Chukwudi | Nnyaha Anthonia. E. | Ikechukwu Samuel Nwaisaac | Okpa Precious Nwaka "Combination Therapy of Carica Papaya and Vernonia Amygdalina Leaf Extracts are as Efficacious as Acts" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5, August 2021, pp.2031-2043, URL: https://www.ijtsrd.com/papers/ijtsrd46293.pdf

The study focused on the comparative determination of the effects of the combination of leaf extracts of Carica papaya (CP) and Vernonia amygdalina (VA) and Artemether-based combination therapy (ACTs) on Plasmodium berghei infected male wistar rats. Fifty (50) male wistar rats, weighing 100 to 150g, were allotted into 5 groups (n=7). Group 2 (negative control) was infected but not treated, groups 3-5 which were infected received 250mg/kg b.w each of CP and VA in combination and 4mg/kg b.w of the two reference ACTs. Treatment was done orally once daily for 3 consecutive days, after which the animals were sacrificed and haematological analysis carried out. Afterwards, an observatory period of 7 days commenced after which another round of sacrifice was done.Before treatment, parasitemia count of animals in groups 3-5 was substantially (p<0.05) higher when juxtaposed with group 2. AST and ALT activities were significantly (p<0.05) elevated in group 3-5 when matched with group 2. Plasmodium berghei induction meaningfully (p<0.05) lowered white blood cell (WBC) at all groups. After treatment, the extracts and drug which notably (p<0.05) lowered plasmodium count, RBC, WBC, PCV, Hb and Platelet levels, did not meaningfully(p>0.05) affect the activities of ALP, AST and ALT. After 7 days of observation, the extracts and drug efficaciously (p<0.05) reduced plasmodium count, WBC and ALP activity further at all groups. These results indicate that the leaf extracts in combination are as efficacious as the ACTs.

Malaria, Parasitemia, Acts, Vernonia Amygdalina, Carica Papaya, Herbal Antimalarials


IJTSRD46293
Volume-5 | Issue-5, August 2021
2031-2043
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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