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Emerging Trends in Adaptive Clinical Trial Designs: Benefits and Limitations

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Emerging Trends in Adaptive Clinical Trial Designs: Benefits and Limitations


A. Shireesha | Kavya Kalva



A. Shireesha | Kavya Kalva "Emerging Trends in Adaptive Clinical Trial Designs: Benefits and Limitations" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-4, August 2023, pp.591-594, URL: https://www.ijtsrd.com/papers/ijtsrd59755.pdf

Adaptive clinical trial designs have gained significant attention in recent years due to their potential to optimize the efficiency and effectiveness of clinical research. These innovative trial designs offer the flexibility to modify study parameters based on accumulating data, thus enabling researchers to make informed decisions in real-time. This review article explores the emerging trends in adaptive clinical trial designs, delving into their benefits and limitations. The benefits of adaptive trial designs include the ability to shorten study duration, reduce sample size requirements, and enhance patient safety by allowing adaptations based on interim results. Adaptive trials also enable researchers to address multiple study objectives within a single trial, making them a valuable tool for exploring multiple treatment strategies simultaneously. Additionally, these designs facilitate the incorporation of new information and treatments as they become available, ensuring that patients receive the most relevant and effective interventions. Despite their potential advantages, adaptive trial designs come with certain challenges and limitations. The need for sophisticated statistical methods, complex trial logistics, and potential operational hurdles can pose difficulties during trial execution. Furthermore, regulatory considerations and the need for rigorous control over the adaptation process require careful planning and clear communication with regulatory authorities. In this review, we discuss various adaptive trial design types, such as group sequential designs, sample size re-estimation, adaptive randomization, and Bayesian adaptive designs. We also highlight real-world examples of successful adaptive trials in different therapeutic areas and discuss the key considerations for implementing these designs effectively.

Adaptive clinical trial designs, emerging trends, benefits, limitations, efficiency, effectiveness, real-time decision-making


IJTSRD59755
Volume-7 | Issue-4, August 2023
591-594
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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