Application of Hydrotrophy in HPLC; Hydrotrophic Solution,  A Novel Cost Effective and Eco-Friendly Mobile Phase for Solubilization of Poorly Water Soluble Drugs

P K Sahoo; Ahammed Unais V P

Title:
Application of Hydrotrophy in HPLC; Hydrotrophic Solution, A Novel Cost Effective and Eco-Friendly Mobile Phase for Solubilization of Poorly Water Soluble Drugs

Authors:
Ahammed Unais V P | P K Sahoo

Cite This Article :

Ahammed Unais V P | P K Sahoo "Application of Hydrotrophy in HPLC; Hydrotrophic Solution, A Novel Cost Effective and Eco-Friendly Mobile Phase for Solubilization of Poorly Water Soluble Drugs" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1, December 2020, pp.1365-1368, URL: https://www.ijtsrd.com/papers/ijtsrd38222.pdf

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Abstract :
Hydrotrophy is a unique molecular phenomenon that posses the ability to increase the solubility of sparingly soluble & poorly soluble drugs in water. A hydrotrophic solution can be defined as adding a solute, that is Hydrotrope, (eg: urea) to the primary one (solvent) and is used as mobile phase for HPLC. High solubility, easy availability, cost effectiveness, eco-friendly are the major advantages which makes the solubilization technique superior. Here we use paracatamol and diclofenac sodium as example to review and conclude this topic. The current review takes the readers throughout a brief summary and features of hydrotropic agents and their different advances towards HPLC technique. It provides an insight of the future perspectives concerned with HPLC and Hydrotropism.

Keywords :
HPLC, Hydrotrophy, Hydrotropism, Hydrotrophic mobile phase, Solubility enhancement

Publication Details:

Unique Identification Number : IJTSRD38222

Published In : Volume-5 | Issue-1, December 2020

Page Number(s) : 1365-1368

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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