Metaclopromide-HCl is an Anti-emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide-HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide-HCl were prepared using HPMC (E5, E15) polymers as film forming agents and polyethylene glycol-400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide-HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action.
Oral fast dissolving films, Metaclopromide, HPMC
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