Fluoroquinolones are well known and among most promising nitrogen containing heterocyclic compounds depicting broad spectrum and potent activities. This article is focussed on the recent patents of fluoroquinolone anti-infective agents including ciprofloxacin, norfloxacin and ofloxacin. Numerous fluoroquinolone derivatives have been found to possess considerable biological activities, which stimulate the research in this field. Fluoroquinolone show several favourable properties like excellent bioavailability, good tissue penetrability and low toxic effects thereby having major pharma- economical advantages over other antibiotics. The primary target for fluoroquinolones is DNA and cellular death is caused by irreversible formation of a ternary fluoroquinolone DNA-DNA gyrase complex. The present review illustrates an insight view on different aspects of fluoroquinolones including chemistry along with the compilation of recent patents of fluoroquinolones and their important derivatives.
Anti-infective, ciprofloxacin, fluoroquinolones, norfloxacin, ofloxacin, patents
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