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A Review on Estimation of Etoricoxib and Paracetamol in Pharmaceutical Dosage Form

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A Review on Estimation of Etoricoxib and Paracetamol in Pharmaceutical Dosage Form


Miss. Poonam Harish Chaure | Prof. Satish Shelke | Dr. Shrish P. Jain



Miss. Poonam Harish Chaure | Prof. Satish Shelke | Dr. Shrish P. Jain "A Review on Estimation of Etoricoxib and Paracetamol in Pharmaceutical Dosage Form" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5, August 2021, pp.1348-1351, URL: https://www.ijtsrd.com/papers/ijtsrd45099.pdf

Non-Steroidal anti-inflammatory drugs deals with complains of pain. It works pharmacologically to inhibit the prostaglandin and be able to reduce pain, fever with inflammation and that is accompanied by other pain disorders. The use of NSAIDs is very effective for reducing pain symptomatically, most widely prescribed and are the first choice in the treatment of inflammatory pain. There are various types of NSAIDs that are known, such as aspirin, paracetamol, ibufrofen, mefenamic acid, indomethacin, diclofenac, piroxicam and nimesulide. From various kinds of NSAIDs, each has advantages and disadvantages that are seen in the therapeutic effect and the side effects caused. Therapeutic effects related to the mechanism of action of this preparation. The use of NSAIDs in children really needs attention. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently prescribed drugs worldwide and are used for relief of inflammatory, chronic (e.g., rheumatoid arthritis, osteoarthritis, and gout), and acute (e.g., headache, postoperative pain, and orthopedic fractures) pain conditions [1]. NSAIDs formulations are also available as over-the counter pharmaceutical preparations. The anti-inflammatory activity of NSAIDs and most of their other pharmacological effects are related to the inhibition of the conversion of arachidonic acid to prostaglandins, which are mediators of the inflammatory process. NSAIDs are potent inhibitors of cyclooxygenase in vitro and in vivo, thereby decreasing the synthesis of prostaglandins, prostacyclin, and thromboxane products . The growing demand for NSAIDs stimulates higher level of quality control of these therapeutic substances and preparations. Hence, there is need to develop new analytical methods for qualitative and quantitative analysis of NSAIDs and their combination drugs.Etoricoxib [1], (5-chloro-2-(6-methyl pyridine-3-yl)-3-(4-methylsulfonyl phenyl) pyridine), is a relatively new non-steroidal anti-inflammatory drug with high selectivity in cyclooxygenase-2-inhibitory activity. It is indicated to relieve the signs and symptoms of osteoarthritis, ankylosing spondylitis and acute gouty arthritis.

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IJTSRD45099
Volume-5 | Issue-5, August 2021
1348-1351
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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