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Advances in Antihypertensive Drug Therapies: A Comprehensive Review of Mechanism, Efficacy, & Side Effects

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Advances in Antihypertensive Drug Therapies: A Comprehensive Review of Mechanism, Efficacy, & Side Effects


Mahesh Sudam Kate | Rushikesh Somnath Murkute | Anand Santosh Murkute | Swapnil Vilas Shinde



Mahesh Sudam Kate | Rushikesh Somnath Murkute | Anand Santosh Murkute | Swapnil Vilas Shinde "Advances in Antihypertensive Drug Therapies: A Comprehensive Review of Mechanism, Efficacy, & Side Effects" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-2, April 2024, pp.738-746, URL: https://www.ijtsrd.com/papers/ijtsrd64777.pdf

Hypertension remains a prevalent health concern worldwide, significantly increasing the risk of cardiovascular diseases. This comprehensive review provides a detailed examination of antihypertensive medications, encompassing their mechanisms of action, classification, and associated adverse effects.The discussion begins with an exploration of risk factors contributing to hypertension, emphasizing the importance of lifestyle modifications in reducing susceptibility. Subsequently, the signs and symptoms indicative of elevated blood pressure are outlined to facilitate early detection and intervention.The main focus of the review is on antihypertensive drugs, starting with diuretics, which act by promoting diuresis and sodium excretion. Thiazide, loop, and potassium-sparing diuretics are examined in depth, elucidating their pharmacokinetics and adverse effects.Renin-angiotensin system inhibitors, including ACE inhibitors, ARBs, and direct renin inhibitors, are discussed next, emphasizing their role in regulating blood pressure and protecting target organs from hypertensive damage. The pharmacokinetic profiles and potential adverse effects of each class are thoroughly examined.Sympathetic inhibitors, such as beta-adrenergic and alpha-adrenergic blockers, are then reviewed for their efficacy in mitigating hypertension through modulation of sympathetic pathways. Pharmacokinetic considerations and adverse effects are highlighted to guide clinical decision-making.Finally, calcium channel blockers and vasodilators are explored for their vasodilatory effects and ability to reduce peripheral resistance. Pharmacokinetic properties and associated adverse effects are discussed to inform therapeutic management.Overall, this review offers a comprehensive understanding of antihypertensive medications, providing clinicians with valuable insights into their mechanisms, classification, and adverse effects to facilitate optimal treatment strategies and improve patient outcomes in the management of hypertension.

Drug Therapies, health, antihypertensive medications


IJTSRD64777
Volume-8 | Issue-2, April 2024
738-746
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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