Many drugs which have low solubility and high permeability poorly soluble and insoluble drug profile creates problems in pharmaceutical industry. The low dissolution rates and profile lower the bioavailability of drug when administered orally.Various techniques which review for enhancement of solubility of poorly water soluble drug techniques like solid dispersion, complexation, co solvency, hydrotropy, for improvement of poorly water soluble drug.The purpose of this review article is to describe the techniques of achievement of improved bioavailaibilty and absorption. Porosity and wettability improves and enhances the solubility and dissolution rate. The primary aim of this review is to improve the solubility and Bioavailability of drugs because of their low solubility and dissolution rate and leading to improving the poorly water soluble drugs. The techniques which leads to enhancing the poorly soluble drugs and desired activity is obtained.The solubility enhancement is most challenging aspect foe drug development pharmaceutically active ingredient with low solubility which creates problems in dru7g development and innovation.
Bioavalability, solubility, cosolvent, solubility enhancement, nanosuspension, dispersion, emulsion, pH
International Journal of Trend in Scientific Research and Development - IJTSRD having
online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International
Journal which provides rapid publication of your research articles and aims to promote
the theory and practice along with knowledge sharing between researchers, developers,
engineers, students, and practitioners working in and around the world in many areas
like Sciences, Technology, Innovation, Engineering, Agriculture, Management and
many more and it is recommended by all Universities, review articles and short communications
in all subjects. IJTSRD running an International Journal who are proving quality
publication of peer reviewed and refereed international journals from diverse fields
that emphasizes new research, development and their applications. IJTSRD provides
an online access to exchange your research work, technical notes & surveying results
among professionals throughout the world in e-journals. IJTSRD is a fastest growing
and dynamic professional organization. The aim of this organization is to provide
access not only to world class research resources, but through its professionals
aim to bring in a significant transformation in the real of open access journals
and online publishing.