Design and Development of Effervescent Floating Tablet Dapagliflozin

Shweta Gedam; Swati Talele | Anil Jadhav; Samadhan Mali

Title:
Design and Development of Effervescent Floating Tablet Dapagliflozin

Authors:
Samadhan Mali | Shweta Gedam | Swati Talele | Anil Jadhav

Cite This Article :

Samadhan Mali | Shweta Gedam | Swati Talele | Anil Jadhav "Design and Development of Effervescent Floating Tablet Dapagliflozin" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5, August 2020, pp.1675-1685, URL: https://www.ijtsrd.com/papers/ijtsrd31674.pdf

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Abstract :
The objective of the present study was to formulate and evaluate Effervescent Floating Tablet of Dapagliflozin for the treatment of antidepressant agent. Tablets were prepared by direct compression using directly compressible polymers such as HPMC K4M, and Carbopol 934 were evaluated for drug-excipient compatibility, density, buoyancy test, swelling study, drug content and In-Vitro release profile. Sodium bicarbonate and citric acid were used producing effervescent base for buoyancy of tablets. Analysis of drug release from tablet indicates drug release by zero order, first order rate kinetics. No significant change was observed in physical appearance, drug content, floatability or in-vitro dissolution pattern after storage at 450C/750C RH for three months.

Keywords :
Floating effervescent tablet, GIT, Dapagliflozin, HPMC K4M, Carbopol 934

Publication Details:

Unique Identification Number : IJTSRD31674

Published In : Volume-4 | Issue-5, August 2020

Page Number(s) : 1675-1685

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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