Formulation Development and In-Vitro Evaluation of Microsponge Drug Delivery System of Antifungal Drug

Sanjay R. Arote; Vilas S. Bhagat

Title:
Formulation Development and In-Vitro Evaluation of Microsponge Drug Delivery System of Antifungal Drug

Authors:
Vilas S. Bhagat | Sanjay R. Arote

Cite This Article :

Vilas S. Bhagat | Sanjay R. Arote "Formulation Development and In-Vitro Evaluation of Microsponge Drug Delivery System of Antifungal Drug" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3, April 2021, pp.654-661, URL: https://www.ijtsrd.com/papers/ijtsrd39870.pdf

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Abstract :
A Microsponge Delivery System (MDS) is patented, highly cross-linked, porous, polymeric microspheres that can entrap wide range of actives and then release them onto the skin over a time and in response to trigger. It is a unique technology for the controlled release of topical agents and consists of microporous beads, typically 10-25 microns in diameter, loaded with active agent. In this study, Ketoconazole microsponges were prepared by using quasi-emulsion solvent diffusion method. The microsponges thus prepared, were evaluated for production yield, loading efficiency, particle size analysis, in-vitro release study of microsponges, and stability. Hence, the present work concluded that MDS has a great potential in topical delivery of drugs like Ketoconazole, with added advantage of reduction in irritation profile due to the controlled release and possible enhancement in the activity due to amorphization of the drug.

Keywords :
Microsponge, microporous beads, particle size analysis

Publication Details:

Unique Identification Number : IJTSRD39870

Published In : Volume-5 | Issue-3, April 2021

Page Number(s) : 654-661

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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