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Research Article of Formulation and Evaluation of Fast Dissolving Tablet of Nitrendipine

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Research Article of Formulation and Evaluation of Fast Dissolving Tablet of Nitrendipine


Shrikant Suryawanshi | Sheetal Gondkar | Rishikesh Bachhav



Shrikant Suryawanshi | Sheetal Gondkar | Rishikesh Bachhav "Research Article of Formulation and Evaluation of Fast Dissolving Tablet of Nitrendipine" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-2, February 2022, pp.416-422, URL: https://www.ijtsrd.com/papers/ijtsrd49225.pdf

Objective: The aim of present study is to formulate fast dissolving tablet of Nitrendipine, the drug will be directly absorbed into systemic circulation through buccal mucosa and lead to produce immediate action. Methods:Fast dissolving tablets of Nitrendipine were prepared by wet granulation method. Required quantity of drug and other excipients were weighed and sieved from sieve no.60 for finding homogenous mixer, then a damp mass of mixer was prepared by using distilled water as a solvent, Damp mass was passed through sieve no. 10 and dried the granules at 50 °C till moisture remaining less than 2% Results: All the formulated tablets met the pharmacopoeias standard of uniformity of weight, percentage friability, thickness, and drug content. The in vitro disintegration and dispersion studies were also performed, which shows very good bioavailability and drug release profile. Accelerated stability studies were done for four weeks and found that no significant change in drug content and other parameters like hardness and in vitro dispersion time after four weeks even at 50 °C. It may be predicted that formulation will be stable for more than one year. Conclusion: The present investigation successfully formulated mouth dissolving tablets of Nitrendipine with improved drug release profile. The formulation was chosen because it showed good results in terms of cumulative drug release, disintegration time, hardness and friability. The dissolution study of this formulation showed an increase in the cumulative % drug release.

Fast dissolving tablets, Nitrendipine, Bioavailability, Wet granulation method, Carr’s index


IJTSRD49225
Volume-6 | Issue-2, February 2022
416-422
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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