The primary objective of this work was to develop a mouth dissolving film with Ziprasidone HCI, along with bioenhancer quercetin and basic ingredients like polymers, plasticizers, sweetener, saliva stimulating agent and flavor. The films were prepared by solvent casting I method. Quercetin enhances dissolution of drug which results in increase in % CDR upto 99%. HPMC E5 cps, which was not able to impart thickness to the film, HPMC E15 shown good flexibility. The plasticizer propylene glycol which was not able to impart flexibility and folding endurance to the film. PEG 400 produced good folding endurance, tensile strength and percent elongation. The optimized formulation (F3) was shown good mouth feel, folding endurance, instant drug release as well as good mechanical properties. The F3, shown less disintegration time of 31 seconds and 95% drug released within 3 minutes. Therefore it was concluded that rapid drug release was achieved for immediate onset of action using quercetin as natural bioenhancer which is beneficial and gives maximum drug release when compared to conventional dosage form.
Ziprasidone HCL, bioenhancer, mouthdissolving oral film, solvent casting
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