The cancer-immunity cycle is characterized by various stimulatory and inhibitory factors, which together regulate the immune response and halt the extreme response that may lead to autoimmune disease. Immunotherapy of cancer has rejuvenated the field of tumor immunology and revolutionized treatment options. In the present review, we discussed the recent advances in different molecular mechanisms of cancer immunotherapy. An immunotherapy is a advanced treatment that boosts humoral and cellular immunity rather than using chemotherapy or radiation-based strategy associated with non-specific targets and toxic effects on normal cells. Immune checkpoint inhibitors and T cell-based immunotherapy have already exhibited significant effects against solid tumor and leukemia. Tumor cells that escape immune surveillance create a major obstacle to acquiring an effective immune response in cancer patients. The previous year’s worldview for cancer treatment has advanced from general to more precise therapeutic approaches. Chemotherapies were first distinguished as the most reliable and brief therapy with promising outcomes in cancer patients. It is a breast cancer is the most commonly diagnosed cancer in women and is a leading cause of cause death in women worldview. Despite the available treatment options, such as surgery, chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy, breast cancer treatment remains a challenge. The FDA approvals of immunotherapeutic drugs underscore the progress made. Antibody engineering has further advanced the production of specialized and potent humanized monoclonal antibodies for clinical use.
Cancer immunotherapy, Targeted-therapies, Immune checkpoint, Monoclonal Antibodies (mAbs), CAR-T cell therapy, Antibody Drug Conjugate (ADCs), Cytokines
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