Home > Pharmacy > Pharmaceutics > Volume-8 > Issue-3 > Development and Assessment of Floating Pulsatile Drug Delivery Systems for Felodipine

Development and Assessment of Floating Pulsatile Drug Delivery Systems for Felodipine

Call for Papers

Volume-8 | Issue-6

Last date : 27-Dec-2024

Best International Journal
Open Access | Peer Reviewed | Best International Journal | Indexing & IF | 24*7 Support | Dedicated Qualified Team | Rapid Publication Process | International Editor, Reviewer Board | Attractive User Interface with Easy Navigation

Journal Type : Open Access

First Update : Within 7 Days after submittion

Submit Paper Online

For Author

Research Area


Development and Assessment of Floating Pulsatile Drug Delivery Systems for Felodipine


Mr. Kalpesh S. Patil | Prof. Kalpeshkumar S. Wagh



Mr. Kalpesh S. Patil | Prof. Kalpeshkumar S. Wagh "Development and Assessment of Floating Pulsatile Drug Delivery Systems for Felodipine" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-3, June 2024, pp.1134-1146, URL: https://www.ijtsrd.com/papers/ijtsrd67104.pdf

This study developed various formulations of floating pulsatile drug delivery systems (FPDDS) for Felodipine using different polymers and excipients, aiming to synchronize drug release with physiological rhythms for improved hypertension and angina treatment. Optimization involved adjusting polymer concentrations, excipients ratios, and coating thicknesses to achieve desired release behavior. In vitro studies demonstrated promising results regarding floating behavior and release kinetics, with favorable drug release profiles in simulated conditions. Comprehensive data analysis confirmed the efficacy and feasibility of the drug delivery system. Materials, including Felodipine and various excipients, were procured and their identities confirmed via UV-visible scans and FT-IR spectra. Felodipine showed maximum absorbance at 363 nm with a linear calibration curve in methanol. Solubility studies indicated variable solubility across different solvents. The formulations exhibited excellent flow properties, with formulation F4 showing optimal characteristics. Post-compression parameters for tablets (C1-C3) met USP criteria, with formulation F8 demonstrating the best performance. Compatibility studies and DSC analysis indicated good stability and compatibility of components. Overall, the FPDDS tablets showed promising results in achieving the desired drug release profile, with formulation F8 emerging as the most effective.

Felodipine, FPDDS, DSC, FT-IR etc


IJTSRD67104
Volume-8 | Issue-3, June 2024
1134-1146
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

Thomson Reuters
Google Scholer
Academia.edu

ResearchBib
Scribd.com
archive

PdfSR
issuu
Slideshare

WorldJournalAlerts
Twitter
Linkedin