This study developed various formulations of floating pulsatile drug delivery systems (FPDDS) for Felodipine using different polymers and excipients, aiming to synchronize drug release with physiological rhythms for improved hypertension and angina treatment. Optimization involved adjusting polymer concentrations, excipients ratios, and coating thicknesses to achieve desired release behavior. In vitro studies demonstrated promising results regarding floating behavior and release kinetics, with favorable drug release profiles in simulated conditions. Comprehensive data analysis confirmed the efficacy and feasibility of the drug delivery system. Materials, including Felodipine and various excipients, were procured and their identities confirmed via UV-visible scans and FT-IR spectra. Felodipine showed maximum absorbance at 363 nm with a linear calibration curve in methanol. Solubility studies indicated variable solubility across different solvents. The formulations exhibited excellent flow properties, with formulation F4 showing optimal characteristics. Post-compression parameters for tablets (C1-C3) met USP criteria, with formulation F8 demonstrating the best performance. Compatibility studies and DSC analysis indicated good stability and compatibility of components. Overall, the FPDDS tablets showed promising results in achieving the desired drug release profile, with formulation F8 emerging as the most effective.
Felodipine, FPDDS, DSC, FT-IR etc
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