Page 61 - Special Issue Modern Trends in Scientific Research and Development, Case of Asia

International Journal of Trend in Scientific Research and Development (IJTSRD)
Special Issue on Modern Trends in Scientific Research and Development, Case of Asia
Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470

The Effect and Significance of Vitamin D

on the Course and Effects of Pregnancy

Isroilova Guljannat Pardabaevna , Azimova Komila Islomovna , Juraeva Gulnora Ergashevna
1
2
1
1 Assistant of the Department of “Obstetrics and Gynecology”, The Head of the 6th Year Student,
2
1,2 Samarkand State Medical Institute, Samarkand, Uzbekistan

ABSTRACT with low body mass, gestational diabetes, preterm birth,
Background. The high prevalence and negative effects of preeclampsia, inflammatory reactions. [2]
vitamin D deficiency is a problem for a wide range of
specialists worldwide. Pregnant and lactating women are at Materials and methods
risk for vitamin D deficiency, as evidenced by the results of An analysis of 18 sources of foreign literature on this topic
many epidemiological studies. Vitamin D plays an was carried outInfluence of vitamin D on satellites, especially
important role in providing the mother-placenta-fetus on trophoblast cells.
system, including implantation, placenta formation,
embryogenesis, intra- and postnatal periods. Vitamin D The placenta contains all the components of the signaling
deficiency leads to placental insufficiency, low birth weight, system of vitamin D (VDR, RXR, CYP27B1 and CYP24A1).
gestational diabetes, premature birth, preeclampsia, and an Weisman et al. [2]
increase in the inflammatory response.
It was found that detsidualnaya tissue in the placenta is able
The purpose of the study: an analytical review of the role to synthesize 1,25 (OH) 2D and 24,25 (OH) 2D, which
and importance of vitamin D during pregnancy in modern
predispose to the formation of cytokines, granulocytes,
scientific literature.
macrophages 2 (GMCSF-2), stimulating colony a (TNF-). a),
Materials and methods. An analysis of 18 foreign literary suppresses the synthesis of protivovospalitelnogo
sources on this topic was carried out interleykina-6 (IL-6) and increases the indicators of TsAMF
in detsidualnyx cells and cytotrophoblastax [3, 5, 6].
Conclusion. Vitamin D plays an important role in the

system of pregnant women, the placenta and the fetus,
especially during implantation, placenta formation, In the case of using vitamin D after exposure to E. coli on the
third row of trophoblast cell cultures, a relatively low
embryogenesis, intra- and postnatal period. According to
infection rate was confirmed compared to the case without
the literature review: Low level 25 (ON) D has an adverse
using vitamin D [6,7]. This indicates a high level of SAMR. It
effect on the course of pregnancy, outcome, fetal follows that adding vitamin D to the diet with a serum 25
development, and infant health. Eliminating vitamin D
(OH) D level <30 ng / ml (vitamin D deficiency or deficiency)
deficiency has a positive effect on pregnancy outcomes and
during pregnancy may reduce infectious processes.
baby's health, i.e. serious complications during pregnancy -

preeclampsia, gestational diabetes, placental insufficiency, Functions of vitamin D during pregnancy
chronic infection and other diseases are significantly
The satellite has been proven to be capable of synthesizing
reduced.
1.25 (OH) 2D. Placental product - 1.25 (PO) 2D. During

KEYWORDS: 25 (OH) 2D, 1.25 (OH) 2D, vitamin D deficiency, pregnancy, against the background of massive synthesis of
preeclampsia, gestational diabetes this vitamin, the rate of entry of this vitamin into the kidneys
increases, which leads to the accumulation of ego [7].
INTRODUCTION
High prevalence and negative consequences of vitamin D Observations have shown that the level of 1.25 (OH) 2D in a
deficiency are a problem for many professionals in the recent series in the third trimester of pregnancy was twice
world. Vitamin D deficiency is associated with health risks, as high as in non-pregnant women and in the postpartum
including cardiovascular disease, cancer, metabolic period [8, 9]. 1.25 (OH) 2D is a link in the auto- and
syndrome, bone marrow, autism, multiple sclerosis, diabetes paracrine immune systems and has been shown to be
and mental health. It is proved that vitamin D deficiency synthesized during pregnancy [10]. 1.25 (OH) 2D inhibits the
causes infertility, affects the longevity of pregnancy and good release of Th1 cytokines and increases the amount of Th2
health (in the womb and in the late adulthood). [1] (Th2 cytokines predominate during implantation) [10, 11].
This modulation of the immune system prevents the
Pregnant and breastfeeding women are exposed to the risk implanted embryo from separating. 1.25 (OH) 2D also
of vitamin D deficiency, which is confirmed by the results of promotes the transformation of the endometrium into
many epidemiological studies. Vitamin D plays an important decidual cells [12, 13]. An important gene for embryonic
role in supporting the maternal-placental-fetal system, implantation and myeloid differentiation in early gestational
including implantation, formation of the placenta, age increases the synthesis of HOXA10 [13, 14]. It was
embryogenesis, intra and postnatal periods. Deficiency of reported that 1,25 (OH) 2D-syncytiotrophoblasts control
vitamin D leads to placental insufficiency, birth of children secretion, secretion and increase the synthesis of steroid

ID: IJTSRD35881 | Special Issue on Modern Trends in Scientific Research and Development, Case of Asia Page 56