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International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470

1. When used with an appropriate peak focal intensity in
situ, HIFU can increase the tissue temperature in the
focal zone to 80-100 ° C for a very short exposure time
(1-10 s) while maintaining the intermediate tissue
temperature at a physiologically safe level;
2. HIFU does not come into contact with the treated tissues
and organs;
3. HIFU forms sharply limited and predictable lesions. The
size and shape of each lesion depends on the width of
the ultrasound beam, the intensity and duration of
exposure [31, 32].
4. When the individual lesions are combined in a matrix
format, a large contiguous lesion of the desired size and
shape can be created [33].
5. As the tissue temperature rises rapidly, the need for
blood transfusion is minimized during HIFU treatment
[34, 35].

6. The energy of ultrasound does not ionize and can be
used repeatedly.
7. The HIFU procedure can be performed on an outpatient
basis

Thanks to the receipt of the US-made Sonablate®-500 Fig. 1. Equipment for ultrasonic ablation of
device, for the first time in Central Asia in 2014, the Intramed hyperplasia tissue
clinic in the city of Samarkand began to use HIFU-therapy for
Prostate Sonablate®-500
BPH. The Sonablate®-500 System has been specially The procedure was performed under spinal anesthesia after
designed for the treatment of the prostate. Its sophisticated
placing the patient on his back in a lithotomy position with
software allows, due to technologically advanced electronics,
raised and bent legs on a conventional operating table. A
to provide accurate and safe treatment of patients with BPH.
Foley catheter 16-18 Ch. Was inserted into the bladder. The
Clinical application of HIFU for BPH using the bladder is then filled with distilled water. A high-frequency
Sonablate® 500 device transducer, placed in a balloon filled with degassed liquid
The device was developed after extensive animal safety (Fig. 2) at room temperature or cooled, is inserted into the
research, analytical computer simulations and laboratory rectum, which provides visual control of the prostate against
research. The Sonablate® 500 system is a medical device the background of the catheter and selection of the ablation
that uses high-intensity focused ultrasound (HIFU) energy to zone. Cooling of the rectal wall is carried out using a special
induce thermal coagulation tissue necrosis in a selected area device - the Sonachill ™ cooler (Fig. 3).
at a specified distance from the focused transceiver element
(s). A unique feature of the Sonablate® 500 system is the use
of technology using the only TRUST ultrasound transceiver
(transrectal ultrasound scanning and therapy) capable of
performing both imaging and treatment. This dual-function
piezoelectric ultrasonic transceiver is located in the
transrectal probe and provides an accurate positioning of the
focus of treatment, as well as visualization of the treatment
process in real time; images are updated after each
treatment cycle [36]. The Sonablate®-500 system includes a
console, digital thermal printer, flat screen monitor, and two
transrectal probes with two transceivers with different focal
lengths, an articulated probe handle and a cooler module.
There are other probes with different focal length
combinations that are not included with the standard
Sonablate®-500 system.

Fig. 2 Ultrasonic transducer for HIFU therapy, filled
with degassed liquid.

ID: IJTSRD41125 | Special Issue on Innovative Development of Modern Research Page 143