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International Journal of Trend in Scientific Research and Development (IJTSRD)
Special Issue on Innovative Development of Modern Research
Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470

Role of HIFU Therapy in Treatment of Benign

Prostate Hyperplasia (Sonablate®-500 Equipment)

Shodmonova Z. R, Yusupov Dj. F, Gafarov R. R, Batirov B. A

Samarkand State Medical Institute, Samarkand, Uzbekistan

ABSTRACT patients with BPH is multifaceted and complex; its causes are
The health and quality of life of elderly men is directly bladder outlet obstruction (mechanical and dynamic
dependent on non-neoplastic diseases, among which benign components) and impaired detrusor function. It is the
prostatic hyperplasia (BPH) is of particular importance. urinary disorders, represented by the symptoms of the lower
Currently, various methods of minimally invasive surgical urinary tract (LUTS), that are the main reason for the decline
treatment of BPH are flourishing. Among the methods that in the quality of life in patients with BPH. Any method of
can rightfully be considered the gold standards of surgical treating prostate adenoma is aimed primarily at eliminating
treatment of BPH (transurethral resection of the prostate, or reducing the intensity of LUTS [4].
laser enucleation of the prostate), a special place is
occupied by borderline techniques that work at the junction Currently, the assessment of the results of BPH treatment
consists of two parameters: life expectancy and its quality. It
of conservative and surgical treatment of BPH. Such
is the patient's quality of life that is of particular economic
techniques include HIFU (High Intensity Focused
and social importance. In recent years, the success of
Ultrasound) or transrectal ablation with high-intensity
focused ultrasound, which allows directed ultrasound to urologists in the treatment of BPH is quite significant, since
they have mastered endoscopic and laparoscopic methods,
destroy deep tissue without damaging nearby healthy
and robotic-assisted technologies are being actively
areas. In the focusing area, the intensity of ultrasound
reaches a very significant level, which is sufficient for a local introduced [1, 2]. The choice of the method of treatment in
patients with symptomatic BPH depends on many factors:
increase in the tissue temperature in the focusing area up to
medical, economic and social, in this connection, the
70-100 ° C. This leads to tissue necrosis of prostatic
treatment of BPH remains one of the urgent problems of
hyperplasia, and then, after rejection of the necrotic ablated
areas, to improvement. Lower urinary tract symptoms modern urology. Many of the existing modern methods of
surgical treatment of this pathology, despite their
associated with BPH.
effectiveness, carry the risk of intraoperative, early and late

KEYWORDS: prostatic hyperplasia, ultrasound ablation, postoperative complications. [3, 4].
transrectal, minimally invasive
Until now, the generally accepted "gold standard" of surgical
treatment of BPH due to its safety and effectiveness,
Relevance: including long-term results, is transurethral resection of the
The increase in the life expectancy of the population has led
prostate (TURP). But this procedure is not devoid of such
to the fact that the proportion of elderly and elderly people intraoperative complications as bleeding, hyponatremia, and
has increased, in connection with which the structure and less often TUR syndrome. Despite this, TURP has been the
level of morbidity have changed. The health and quality of
procedure of choice in the surgical treatment of vesical
life of men over 50, according to the modern gerontological
obstruction (IVO) due to BPH for more than 50 years.
concept, is directly dependent on non-oncological diseases: However, the significant number of complications after TURP
benign prostatic hyperplasia, stress, cardiovascular diseases, necessitates the search for new alternative methods of
erectile dysfunction. Given the increasing trend towards an
treatment. In recent years, the procedures of transrectal
increase in life expectancy and an aging population, the
laser enucleation of prostatic hyperplasia, which include
problem of BPH treatment seems to be very urgent [1, 2]. holmium and thulium laser enucleations, have become very
BPH is a disease characterized by overgrowth of prostate important. Today, many authors refer these techniques to
tissue that surrounds the urethra, resulting in obstruction of the new "gold" standard of surgical treatment for BPH.
the urinary tract. In the structure of urological pathology in However, these procedures are not without complications
the United States, the following are sequentially distributed and are often accompanied by ejaculation disorders, which
in frequency: diseases of the prostate gland, urinary significantly reduce the quality of life of patients with BPH,
incontinence, erectile dysfunction, and urolithiasis. Every especially in sexually active patients. All of the above
year from 7 to 8 million patients seek medical help, required further search and development of new minimally
concerned about difficulty urinating due to the presence of invasive technologies in the treatment of BPH. Over the past
prostatic hyperplasia [2, 3]. In Germany, about 40% of decades, many new experimental treatments have been
urological beds are occupied by patients with this disease. developed, such as thermal tissue destruction, balloon
Numerous studies of domestic and foreign urologists have dilatation, prostatic stents, transrectal microwave
shown that although the most vulnerable to prostate hyperthermia, aqua ablation [5, 6].
adenoma disease is the age from 60 to 70 years, however,
The history of the method
over the past 20-30 years there has been a significant Transrectal therapy with high-intensity focused ultrasound
rejuvenation of patients with prostate diseases. According to ((HIFU), English - High Intensity Focused Ultrasound (HIFU))
autopsy data, BPH is detected in more than 90% of men over
is one of the methods of treatment of prostate adenoma,
80 years old. [3]. The mechanism of urination disorders in

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