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International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470

80% of the total number of injuries to the bones of the facial and a decrease in the size of lymph nodes, including those
skeleton. Despite some success in the treatment of this surrounded by perifocal inflammation. In addition,
category of patients, the percentage of infectious and lymphotropic therapy in the treatment of chronic forms of
inflammatory complications in mandibular fractures remains osteomyelitis of the lower jaw promotes bone regeneration,
high and varies from 5.5 to 41% [17]. It is clinically proven which is confirmed by orthopantomography data [21].
that lymphotropic therapy significantly reduces the duration
Observations of E. V. Turchina (2017) indicate that in
of treatment and reduces the course doses of antibiotics by 3
times, as well as the risk of allergic reactions. This technique patients with CHLO abscesses, after intramuscular
administration of ampicillin in the blood after 4 hours, its
is easy to use, does not require special equipment and can be
concentration decreased by more than three times
recommended for wide practical use [18].
(1.00±0.44 mcg/ml). Moreover, some of the subjects had a
Prikhodnaya V. A. (2008) believes that the method of zero ampicillin concentration (from 0 to 6.5
lymphotropic antibacterial therapy in the complex treatment micrograms/ml). In this group of subjects, the half-
of open fractures of the lower jaw can influence the elimination period ranged from 0.25 to 1.5 hours.
etiotropic and pathogenetic mechanisms. Having an Meanwhile, after lymphotropic administration of the
advantage over the traditional method of drug antibiotic in the mastoid process of the temporal bone in 4
administration: it contributes to a longer maintenance of hours, its concentration reached 4.24 ±0.17 micrograms / ml,
optimal concentrations of the antibiotic in the lymphatic and the half-elimination period was from 20.6 to 43.5 hours.
system, blood, in the focus of inflammation, allowing you to The creation of the necessary concentration of the antibiotic
significantly reduce endogenous intoxication of the body, throughout the entire period of treatment had a positive
normalize the drainage function of the lymphatic system of effect on the clinical course of the disease.
the maxillofacial region. The method of lymphotropic
antibacterial therapy has no significant restrictions in use, is Lymphotropic administration of an antibiotic 1 cm below the
mastoid process of the temporal bone in acute purulent
easily accessible, and allows you to reduce the consumption
periostitis of the jaw in the molar region leads to earlier,
of medicines. Complex therapy of open mandibular fractures
compared with other methods of treatment, elimination of
with the use of lymphotropic antibacterial therapy promotes
rapid relief of inflammation, providing prevention of post- antigenic substances from the site of inflammation, since in
the cytogram of leukocyte infiltrates in the deep parts of the
traumatic inflammatory complications.
gingival mucosa 2 days after the start of treatment,
Currently, it is also proposed to increase the effectiveness of monocytes and macrophages are present in greater
the treatment of periapical abscess with the help of numbers, which means that by this time the purulent-
lymphotropic drug therapy using the drugs rocefin and necrotic processes are completed and more pronounced
tactivin. Inflammation of the tissues surrounding the tooth is reparative [2].
quite common, which is mainly due to microorganisms that
enter the periodontium through the root canal, periodontal Chronic diseases of the oral mucosa are a serious problem in
dentistry. Such diseases include lichen planus, which is
pocket, or hematogenous and lymphogenic pathways.
characterized by a torpid course, polymorphism of clinical
Determining the effectiveness of the results of conservative manifestations, complexity of diagnosis and low
treatment of exacerbations of chronic periodontitis consists effectiveness of treatment [22]. In this regard, various
of an analysis of the timing of relief of acute inflammation methods of complex pathogenetic therapy using a wide
and the duration of the rehabilitation period of the patient variety of methods and means of treatment are proposed.
[19] Under the influence of lymphotropic therapy is not effective
and ksantinola the nicotinate improves the clinical course of
The evaluation of the obtained results suggests the
lichen planus of the mucous membrane of the oral cavity.
advantage of using the regional lymphotropic method in the
complex treatment of exacerbations of chronic periodontitis The positive dynamics is expressed in the reduction of
in comparison with standard intramuscular administration. unpleasant subjective sensations, the degree of hyperemia,
the size of the lesion area by 2.5 times, the severity of the
According to Savin E. K. (2011), as a result of clinical
papular pattern and the epithelization of erosions. Thus,
radiological studies, a high efficiency of treatment of
lymphotropic administration of derinate and xanthinol
exacerbations of chronic apical periodontitis, in which
nicotinate allows to achieve improvement of the local and
lymphotropic therapy was used, was established. general condition of the patient, stabilization of
Lymphotropic therapy activated the reparative processes in
immunological parameters, stable clinical results and longer
the bone tissue of apical periodontitis, reducing the time for
remission [23].
reducing the size and eliminating the periapical pathological
focus of destruction in the area of the root apex. It is advisable to use the lymphotropic method of drug
administration to increase the effectiveness of therapeutic
The analysis of the effect of lymphotropic therapy on the
measures for oral candidiasis, since this disease causes
local manifestations of osteomyelitis of the lower jaw was
changes not only in the epithelium of the oral mucosa, but
performed. It is proved that it more effectively stops them also in the underlying tissues [24]. Regional lymphotropic
than the known methods of postoperative treatment. This is
administration of the antioxidant drug mexidol was used in
manifested in an accelerated and more pronounced decrease
the complex treatment of oral candidiasis. Mexidol initiates
in the circulatory manifestations of inflammation, such as the detoxification function of the oral cavity, restores the
edema, hyperemia, and the condition of the mucous
antioxidant potential, normalizes the differentiation of
membrane of the transitional fold of the oral cavity [20].
epithelial cells and increases their resistance to the adhesion
There was an increase in the antibacterial activity of the
of fungi of the genus Candida. Lymphotropic administration
antibiotics used, which is indirectly evidenced by a decrease of mexidol shortens the treatment time of patients and
in the number of people with purulent fistula compartments
reduces the frequency of relapses of the disease [25].
ID: IJTSRD39826 | Special Issue on Innovative Development of Modern Research Page 24