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Based on the direction and nature of treatment, S. U. Jumabaev E. S., Jumabaeva S. E., Saidhodzhaeva D. G. (2017)
Dzhumabaev, E. S. Dzhumabaev, and I. R. Fayziev (1986) first believe that regional lymphatic therapy, including regional
developed a classification of lymphatic therapy, according to stimulation of lymphatic drainage, antibiotic therapy and
which it is divided into the following: immunomodulation, lead to better clinical results in
A. Kinds: comparison with traditional methods of treatment, reduce
1. General lymphatic therapy the consumption of medicines by 1.5-2 times, reduce the
2. Regional lymphatic therapy number of injections by 2-3 times, reduce the duration of
treatment by 10 - 25% and the cost of inpatient treatment by
B. Methods of lymphatic therapy:
25-40%.
1. Direct
2. Indirect As indicated by N. N. Nazarov, E. S. Dzhumabaev, Z. K.
Gafurov, A. B. Makhmudov (2018), it is possible to prevent
C. Methods of drug administration
the occurrence of complications in purulent-inflammatory
1. Direct lymphatic therapy-catheterization of
diseases by indirect regional lymphotropic therapy. The
a) the lymphatic vessel
proposed indirect administration of antibiotics allows you to
b) the lymph node
create large concentrations of the drug in the regional lymph
2. Indirect lymphatic therapy: nodes and keep them in the tissues for a long time.
a) through a skin puncture
Semak M. V., Bubnova N. A., Borisova R. P., Shatil M. A. (2017)
b) intraoperative puncture c
believe that conducting a course of lymphotropic
c) percutaneous needle-free injection antibacterial therapy with a temporary pharmacological
d) electrophoresis
block with modern antibiotics in patients with chronic
D. Mechanism of action: osteomyelitis contributes to a faster relief of inflammatory
1. Correction of microcirculation phenomena. In addition, the relapse of the disease occurs in
2. Antibacterial therapy such patients much less often than in patients who received
3. Immunomodulatory therapy traditional treatment. According to Zhanalin B. S. et al (2014)
4. Antitumor therapy introduction of regional lymphotropic therapy in acute
5. Detoxification therapy odontogenic osteomyelitis of the mandible in children has
6. Combined therapy led to optimization of the structure of direct costs, more
efficient use of antibacterial drugs, reducing the number of
E. Regions of therapeutic effects of lymphatic therapy.
days of hospital stay and duration of antibiotic therapy,
According to Gurbanov T. V. (2018) indirect saturation of the improvement of cost/effectiveness.
lymphatic system (lymphotropic therapy) is a promising
method of drug infusion. Its essence consists in the Taking into account the anatomical structure of the salivary
introduction of active substances targeted in a zone gland, the use of lymphotropic therapy in inflammatory and
containing a large number of lymphatic vessels and nodes, dystrophic diseases of the large salivary glands is shown.
which allows you to achieve saturation only of a certain Thus, the parotid glands contain lymph nodes in their
region of the lymphatic system that drains this area. structure. The parotid and submandibular glands are
enclosed in dense capsules, which, when the volume of the
According to Yu. M. Levin et al. (2012), S. U. Dzhumabayeva,
gland increases, create additional interstitial pressure. Thus,
E. S. Dzhumabayeva (2017), endolymphatic therapy, both the conditions that promote lymphotropic therapy are met
direct and indirect, is designed to create an optimal
[13].
concentration of the drug in the lymphatic system "in its
pure form", to ensure its maximum contact with pathogenic Today, several methods of drug delivery to the parotid gland
microorganisms in places of their retention and have been developed. This is a method similar to novocaine
accumulation, mainly in the lymph nodes. blockade of the salivary glands, in which subcutaneous fat is
infiltrated over the parotid salivary gland [13, 14], as well as
The study of Kantemirov O. I. (2001) shows that antibiotics
a method of subcapsular administration of drugs [13, 15].
are a unique group of pharmacological drugs, the These methods have a number of disadvantages associated
effectiveness of which decreases over time. This aspect
with some anatomical and morphological features of the
requires special attention both when evaluating their
structure of the parotid salivary glands. The lobes and
effectiveness and when developing evidence-based
lobules of the gland are surrounded by their own thin, but
approaches aimed at prolonging the terms of their clinical dense shells, between which there is a loose connective
use. In this regard, there was a need to find new ways of
tissue, which makes it difficult for the drug to penetrate and
introducing drugs that would allow them to create long-
spread in the areas of the acinar structures of the glands [13,
lasting therapeutic concentrations in the body without 16]. The results were improved and the treatment of chronic
increasing the dose. One such route of administration is the
inflammatory and reactive dystrophic diseases of the parotid
lymphatic system. The study of the distribution of drugs
salivary glands was shortened by indirect lymphotropic
introduced into the lymph in different groups of lymph nodes
therapy using anatomical intragastric injection of the drug
showed that it is possible to achieve their greatest into the salivary gland, infiltrating its central, lower and
accumulation when administered taking into account the
posterior parts. Injections are administered in areas of the
segmental structure of the lymphatic system.
gland with a low fiber density that are free from the passage
Thanks to the research of the leading lymphologists of our of the branches of the facial nerve [13].
country, S. U. Jumabaev, E. S. Jumabaev, the mechanisms of
To date, the clinical effectiveness of regional lymphotropic
the influence of drugs introduced into the lymphatic vessels,
therapy in the complex treatment of patients with purulent-
the effects on the lymphatic system by physical, chemical,
inflammatory complications of mandibular fractures has also
biological and other agents became clear.
been studied. Fractures of the lower jaw account for about
ID: IJTSRD39826 | Special Issue on Innovative Development of Modern Research Page 23