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Jia L. et al. (2012) believe that FRC are involved in the cardiovascular system: lymphoid couplings of varying
formation of the walls of lymphatic labyrinths (LL) in LN. The complexity of structure surround the tissue channels and
researchers found that LL arise at the periphery of the deep vessels as their attachments-biofilters that regulate the
cortex and at the edge of the follicle, expand towards the cellular and protein composition of the internal environment
medulla and pass into the cerebral sinuses at the cortical- of the body. At the heart of the lymphoid system are closed in
brain border. These structures are populated by densely a circle of blood vessels, through which the (re)circulation of
packed small lymphocytes, do not contain dendritic cells and lymphocytes occurs. The lymphatic bed drains the lymphoid
macrophages. The LL wall consists of three layers: the inner formations, and brings the lymph to some of them for
wall is a layer of flattened lymphatic endothelium (stained on purification. The lymphoid and lymphatic systems are united
LYVE-1); The outer wall is a layer of FRC and their at the periphery in an immunoprotective complex: the
cytoplasmic processes, and the third layer is an amorphous lymphatic bed and the lymphoid tissue around the blood
substance and collagen fibers sandwiched between these microvessels cooperate to ensure the genotypic homeostasis
two layers. Apparently, the LL are the zones of the most of the body, make up the lymphoid-lymphatic apparatus as
rapid transport of lymphocytes to the LN. part of the cardiovascular system.
The movement of lymph depends on the following factors: The lymphatic system plays a leading role in the
consistency of fluid from plasma to interstitial space, and last pathogenesis of purulent-inflammatory diseases (Yu. E.
– to the lymph vessels, the physiological activity of the Vyrenkov 1990-2008, Yarema I. V. et al., 1992-2010), since
organs and the contractility of the walls of lymph vessels and the spread of bacteria and toxins occurs mainly in the
lymph nodes that contain smooth muscle cells; contractions lymphatic vessels and lymph nodes, where they are delayed
of striated muscles, and all kinds of active and passive in the lymphatic system and the so-called toxic depot is
movements of the body and individual organs; a negative formed. In this regard, the lymphotropic administration of
pressure in the large veins of the neck, which are for antibiotics, immunomodulators, antioxidants, and
collectors of the thoracic lymphatic duct, fluctuations in anticoagulants is pathogenetically justified. Drug saturation
intrathoracic pressure during breathing; pulsation of the of the lymphatic system allows you to create high
aorta and arteries[28]. therapeutic concentrations of antibiotics and other drugs on
the pathways of bacterial factors, improve the rheology of
The anatomy and physiology of the lymphatic system, as well
the lymph, which makes it possible to unblock inflamed
as its instant reaction to the pathological process of any
lymph nodes, reduce the likelihood of restriction and
localization and etiology, opens up broad prospects for the abscission of inflammatory infiltrates in the lymphatic
use of lymphotropic therapy in clinical practice.
system.
The main metabolic processes are carried out at the level of
The idea of using lymphatic vessels for the administration of
the microcirculatory bed, which consists of arterioles with a
drugs, in particular antibiotics, was first expressed in the
diameter of 30-200 microns, blood capillaries with a early 50s by B. V. Ognev. Conducting experimental studies, he
diameter of 2-22 microns, venules with a diameter of 40-100
discovered the leading role of the lymphatic system in the
microns, and lymphatic capillaries with a diameter of 10-200
spread of tumor cells from the site of the primary focus, the
microns [6, 7]. In the body, the cells do not adhere directly to
migration of microorganisms with the development of
the blood capillaries, the exchange of substances between lymphangoitis, lymphadenitis and sepsis in inflammation [1].
the cells and the blood occurs through the connective tissue,
which is for them the "tissue of the internal environment" Experimental research and clinical observations allowed us
[8]. The connective tissue is filled with an interstitial to use mainly 2 methods of lymphogenic therapy: direct
substance of a colloidal nature, through which there is a endolymphatic administration of drugs through a
movement of water, electrolytes, substances in a state of catheterized peripheral lymphatic vessel and indirect drug
molecular dispersion, colloids and suspended particles from saturation of the lymphatic system. The latter method is
the bloodstream to the lymphatic system. Normally, minimally invasive, does not require direct surgical
interstitial pressure is close to zero or slightly positive [9]. intervention, special surgical skills, and is available for
The lymphatic system, absorbing water and dissolved doctors to perform in any direction [1]. The results of
crystalloids, colloidal solutions, protein substances, fats, numerous studies in recent years confirming the presence of
complements the venous system in the process of tissue a lymphatic bed in the maxillofacial region, as well as the
metabolism and drainage of the intercellular space. Since the successful application of lymphatic therapy methods in other
diameter of the lymphatic capillaries exceeds the diameter of areas of surgery, contributed to the beginning of their
the blood capillaries, colloidal particles with a size of 20-80 application in dentistry [5].
microns become permeable to the lymphatic system [10].
The advantages of lymphotropic therapy are the following:
The role of the endothelium of lymphatic vessels is not
[12]:
limited to the absorption of colloidal solutions and
create a high concentration of drugs in the drug
suspensions from tissues, it also participates in reactive
changes in connective tissue [11]. Lymphotropic therapy is (antitumor, antibiotics, immunomodulators, proteolysis
inhibitors, analgesics, etc.), which, when administered
based on two main components – the principle of regionarity
normally, do not sufficiently penetrate the drug, are
and the principle of increased interstitial pressure.
quickly inactivated or removed;
Petrenko V. M. (2017) points out that the lymphatic system is increase the concentration and duration of action of the
arranged as a chain of intervalvular segments with different drug in the tissues of the pathological focus;
wall structures, organizes a special path of outflow from the reduce the toxic effect of the drug;
organs (collateral drainage to the veins) of tissue fluid in the increase the passage of the drug in the brain tissue;
form of lymph, and in its composition – antigens. The enhance the analgesic effect of the drug.
lymphoid system looks like a special prefix of the

ID: IJTSRD39826 | Special Issue on Innovative Development of Modern Research Page 22