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International Journal of Trend in Scientific Research and Development (IJTSRD)
Special Issue on Innovative Development of Modern Research
Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470

Increased Cardiac Troponin-T in

Patients without Myocardial Infarction

Khusainova Munira Alisherovna

Samarkand State Medical Institute, Samarkand, Uzbekistan

ABSTRACT was an increase in the level of cardiac troponin-T above the
According to the World Health Organization, the diagnosis diagnostically significant level (more than 0.3 ng / ml). The
of acute myocardial infarction (AMI) is based on two of the exclusion criteria were:
three main criteria: changes in the ECG (up to 25% of
clinical picture of acute coronary syndrome (typical
myocardial infarctions are not reflected in the ECG),
angina attacks);
anginous pain, and increased markers of myocardial
necrosis. In 2000, the European Scientific Society and the ECG changes characteristic of AMI on the first day of
American College of Cardiology made a correction to the inpatient treatment (elevation or severe depression of
definition of AMI, according to which the determining factor the ST segment, the appearance of new Q waves).
in the diagnosis of AMI is the detection of an increased level
All patients underwent a general clinical examination. The
of specific markers of myocardial necrosis — cardiac
level of cardiac troponin-T in the blood (using the device
troponins in the blood. Troponin is a protein that is part of
Cardiac Reader Roche, Germany) was determined at
myofibrils. Cardiac troponin contains three subunits: T, I,
and C. Troponin C is non-specific for the myocardium, in admission, or 14-16 hours after the deterioration of the
condition. ECG registration was performed on admission to
contrast to the T and I subunits, whose structure in the
the hospital and daily. Echocardiography was performed on
contractile fibers of cardiomyocytes differs from similar
proteins of other muscle cells. The widespread use of the the device GE Vivid 7 (USA) according to the generally
accepted method. In addition, the level of transaminases,
determination of cardiac troponins in the blood
urea, creatinine, bilirubin, total protein, MB-CK in the blood
significantly increased the detection of AMI (by 30-200%).
was analyzed, gases, blood electrolyte, acid-base balance
Until recently, it was believed that troponins enter the were examined. Chest radiography was performed at
blood only as a result of the death of cardiomyocytes. admission, in some cases — repeatedly. If necessary, the
However, in recent years, it has been shown that troponins patients underwent ultrasound examination of the
can penetrate into the interstitial space, and then into the abdominal cavity and kidneys, blood culture, and brain CT.
blood, when cardiomyocytes are damaged with an increase
in the permeability of their cell membranes, which can be The severity of the patient was determined based on the
calculation of the SAPS II index, which assumes an
caused not only by AMI, but also by conditions accompanied
assessment of the urgency of the patient's admission to the
by hyper production of pro-inflammatory cytokines (tumor
necrosis factor-α, interleukin-1, etc.). hospital, the presence of chronic diseases, age, temperature,
daily diuresis, blood pressure, heart rate, blood oxygenation
The aim of this study was to analyze the final diagnoses in index (FiO2/PaO2), white blood cells, sodium, potassium,
patients with increased cardiac troponin-T levels without a urea, bicarbonate and bilirubin, as well as an assessment of
clinical picture and characteristic ECG changes in AMI. the level of consciousness on the Glasgow scale.

KEYWORDS: acute myocardial infarction, cardiomyocytes, The final diagnosis was established on the basis of the
cardiac troponin-T, anginous pain analysis of the clinical picture, the study of the dynamics of
the main symptoms, the data of a comprehensive
Materials and methods examination, in some cases — on autopsy.
The study included 54 patients (36 men, 18 women, aged 54
to 87 years, on average-69.8±11.2). The inclusion criterion

Table 1 Mortality of patients included in the study and the level of cardiac troponin-T
Total Number of Troponin-T level in
Troponin-T level in the
Nosological form number of deceased discharged patients
deceased (ng/ml)
patients patients (ng/ml)
AMI 22 11 0.79±0.19 1.62±0.21*
Septic condition 16 9 0.63±0.14 1.66±0.27*
Oncopathology 8 6 0.74±0.49 1.49±0.34
Diabetic nephropathy with CRF 4 2 0.58±0.34 1.59±0.58
Brain infarction 3 1 0.61±0.45 1.31±0.61
B12-deficiency anemia 1 1 0.49 1.69
Note. Here and in Table. 2: * - statistical significance of differences between the level of troponin T in deceased and
discharged patients (p<0.05).

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